Risk factors for amenorrhea in juvenile systemic lupus erythematosus (JSLE): a Brazilian multicentre cohort study
Identifieur interne : 001B05 ( Main/Exploration ); précédent : 001B04; suivant : 001B06Risk factors for amenorrhea in juvenile systemic lupus erythematosus (JSLE): a Brazilian multicentre cohort study
Auteurs : C. A. A. Silva [Brésil] ; M. O. Hilário [Brésil] ; M. V. Febrônio [Brésil] ; S. K. Oliveira ; M. T. Terreri [Brésil] ; S. B. Sacchetti ; F. R. Sztajnbok ; R. Marini ; M. V. Quintero ; B. E. Bica ; R. M. Pereira [Brésil] ; E. Bonfá [Brésil] ; V. P. Ferriani [Brésil] ; T. C. Robazzi ; C. S. MagalhãesSource :
- Lupus [ 0961-2033 ] ; 2007-07.
English descriptors
- Teeft :
- Amenorrhea, Amenorrhea onset, American college, Arthritis rheum, Brazilian multicentre cohort study, Clinical features, Cohort, Cumulative dose, Cyclophosphamide, Demographic features, Disease activity, Disease damage, Erythematosus, Federal university, Gonadal function, Hormonal, Hormonal assessment, Intravenous cyclophosphamide, Ivcyc, Jsle, Jsle patients, Logistic regression analysis, Lupus, Lupus erythematosus disease activity index, Menstrual, Multicentre, Other hand, Ovarian, Ovarian dysfunction, Ovarian failure, Ovarian reserve, Paulo, Pubertal changes, Renal, Renal histopathology, Renal involvement, Rheum, Rheumatology, Risk factors, Silva, Sledai, Systemic, Systemic lupus, Systemic lupus erythematosus, Univariate analysis.
Abstract
We evaluated the prevalence and clinical associations of amenorrhea in 298 female juvenile systemic lupus erythematosus (JSLE) patients (ACR criteria) followed in 12 Brazilian Paediatric Rheumatology centres. Amenorrhea was observed in 35 patients (11.7%) with a mean duration of 7.2 ± 3.6 months. The hormones were performed in 32/35 patients and none of them had FSH and LH levels above and estradiol below the normal range according to pubertal changes. JSLE patients with amenorrhea were younger (15.04 ± 2.5 versus 17.8 ± 3.1 years; P = 0.001), and had a shorter period of time between menarche and current age (3.4 ± 2.9 versus 6.7 ± 5.4 years; P = 0.001). Interestingly, the frequency, cumulative dose, number of pulses and duration of intravenous cyclophosphamide treatment were alike in patients with and without amenorrhea (P > 0.05). In contrast, patients with amenorrhea had significantly higher SLEDAI (P = 0.01) and SLICC/ACR-DI (P = 0.024) scores compared to those without this condition. Independent risk factors identified by multivariate analysis were higher SLEDAI (OR = 1.059; CI = 1.004—1.116; P = 0.034) and SLICC/ACR-DI (OR = 2.125; IC = 1.373—3.291; P = 0.001) scores. Our data suggest that in spite of immunosuppressive therapy, JSLE patients have an adequate ovarian follicular reserve and amenorrhea is particularly associated with disease activity and damage. Lupus (2007) 16, 531—536.
Url:
DOI: 10.1177/0961203307079300
Affiliations:
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Marini</name><affiliation><wicri:noCountry code="no comma">State University of Campinas</wicri:noCountry></affiliation></author><author wicri:is="90%"><name sortKey="Quintero, M V" sort="Quintero, M V" uniqKey="Quintero M" first="M. V." last="Quintero">M. V. Quintero</name><affiliation><wicri:noCountry code="no comma">Santa Casa of Belo Horizonte</wicri:noCountry></affiliation></author><author wicri:is="90%"><name sortKey="Bica, B E" sort="Bica, B E" uniqKey="Bica B" first="B. E." last="Bica">B. E. Bica</name><affiliation><wicri:noCountry code="subField">Janeiro</wicri:noCountry></affiliation></author><author wicri:is="90%"><name sortKey="Pereira, R M" sort="Pereira, R M" uniqKey="Pereira R" first="R. M." last="Pereira">R. M. 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Magalhães</name><affiliation><wicri:noCountry code="subField">Botucatu</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Lupus</title><idno type="ISSN">0961-2033</idno><idno type="eISSN">1477-0962</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage UK: London, England</pubPlace><date type="published" when="2007-07">2007-07</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="531">531</biblScope><biblScope unit="page" to="536">536</biblScope></imprint><idno type="ISSN">0961-2033</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0961-2033</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Amenorrhea</term><term>Amenorrhea onset</term><term>American college</term><term>Arthritis rheum</term><term>Brazilian multicentre cohort study</term><term>Clinical features</term><term>Cohort</term><term>Cumulative dose</term><term>Cyclophosphamide</term><term>Demographic features</term><term>Disease activity</term><term>Disease damage</term><term>Erythematosus</term><term>Federal university</term><term>Gonadal function</term><term>Hormonal</term><term>Hormonal assessment</term><term>Intravenous cyclophosphamide</term><term>Ivcyc</term><term>Jsle</term><term>Jsle patients</term><term>Logistic regression analysis</term><term>Lupus</term><term>Lupus erythematosus disease activity index</term><term>Menstrual</term><term>Multicentre</term><term>Other hand</term><term>Ovarian</term><term>Ovarian dysfunction</term><term>Ovarian failure</term><term>Ovarian reserve</term><term>Paulo</term><term>Pubertal changes</term><term>Renal</term><term>Renal histopathology</term><term>Renal involvement</term><term>Rheum</term><term>Rheumatology</term><term>Risk factors</term><term>Silva</term><term>Sledai</term><term>Systemic</term><term>Systemic lupus</term><term>Systemic lupus erythematosus</term><term>Univariate analysis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the prevalence and clinical associations of amenorrhea in 298 female juvenile systemic lupus erythematosus (JSLE) patients (ACR criteria) followed in 12 Brazilian Paediatric Rheumatology centres. Amenorrhea was observed in 35 patients (11.7%) with a mean duration of 7.2 ± 3.6 months. The hormones were performed in 32/35 patients and none of them had FSH and LH levels above and estradiol below the normal range according to pubertal changes. JSLE patients with amenorrhea were younger (15.04 ± 2.5 versus 17.8 ± 3.1 years; P = 0.001), and had a shorter period of time between menarche and current age (3.4 ± 2.9 versus 6.7 ± 5.4 years; P = 0.001). Interestingly, the frequency, cumulative dose, number of pulses and duration of intravenous cyclophosphamide treatment were alike in patients with and without amenorrhea (P > 0.05). In contrast, patients with amenorrhea had significantly higher SLEDAI (P = 0.01) and SLICC/ACR-DI (P = 0.024) scores compared to those without this condition. Independent risk factors identified by multivariate analysis were higher SLEDAI (OR = 1.059; CI = 1.004—1.116; P = 0.034) and SLICC/ACR-DI (OR = 2.125; IC = 1.373—3.291; P = 0.001) scores. Our data suggest that in spite of immunosuppressive therapy, JSLE patients have an adequate ovarian follicular reserve and amenorrhea is particularly associated with disease activity and damage. Lupus (2007) 16, 531—536.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><noCountry><name sortKey="Bica, B E" sort="Bica, B E" uniqKey="Bica B" first="B. E." last="Bica">B. E. Bica</name><name sortKey="Magalhaes, C S" sort="Magalhaes, C S" uniqKey="Magalhaes C" first="C. S." last="Magalhães">C. S. Magalhães</name><name sortKey="Marini, R" sort="Marini, R" uniqKey="Marini R" first="R." last="Marini">R. Marini</name><name sortKey="Oliveira, S K" sort="Oliveira, S K" uniqKey="Oliveira S" first="S. K." last="Oliveira">S. K. Oliveira</name><name sortKey="Quintero, M V" sort="Quintero, M V" uniqKey="Quintero M" first="M. V." last="Quintero">M. V. Quintero</name><name sortKey="Robazzi, T C" sort="Robazzi, T C" uniqKey="Robazzi T" first="T. C." last="Robazzi">T. C. Robazzi</name><name sortKey="Sacchetti, S B" sort="Sacchetti, S B" uniqKey="Sacchetti S" first="S. B." last="Sacchetti">S. B. Sacchetti</name><name sortKey="Sztajnbok, F R" sort="Sztajnbok, F R" uniqKey="Sztajnbok F" first="F. R." last="Sztajnbok">F. R. Sztajnbok</name></noCountry><country name="Brésil"><region name="État de São Paulo"><name sortKey="Silva, C A A" sort="Silva, C A A" uniqKey="Silva C" first="C. A. A." last="Silva">C. A. A. Silva</name></region><name sortKey="Bonfa, E" sort="Bonfa, E" uniqKey="Bonfa E" first="E." last="Bonfá">E. Bonfá</name><name sortKey="Febronio, M V" sort="Febronio, M V" uniqKey="Febronio M" first="M. V." last="Febrônio">M. V. Febrônio</name><name sortKey="Ferriani, V P" sort="Ferriani, V P" uniqKey="Ferriani V" first="V. P." last="Ferriani">V. P. Ferriani</name><name sortKey="Hilario, M O" sort="Hilario, M O" uniqKey="Hilario M" first="M. O." last="Hilário">M. O. Hilário</name><name sortKey="Pereira, R M" sort="Pereira, R M" uniqKey="Pereira R" first="R. M." last="Pereira">R. M. Pereira</name><name sortKey="Silva, C A A" sort="Silva, C A A" uniqKey="Silva C" first="C. A. A." last="Silva">C. A. A. Silva</name><name sortKey="Terreri, M T" sort="Terreri, M T" uniqKey="Terreri M" first="M. T." last="Terreri">M. T. Terreri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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